Current email setup: osx + homebrew + sup + davmail + getmail

 At work we have an Exchange server for email (no POP3/IMAP) and most people use Outlook. However I prefer not to use outlook, here's what I came with:

• Sup as email client
• DavMail for POP3/SMTP
• getmail for fetching email
• Homebrew for unix-ish environment (yup, that's OSX for you)

 Setup is a bit complicated, but once you're there - email is a bliss (well, as much as email can be :)

DavMail

Install DavMail from the .dmg. Run it and point it to the exchange server URL and have it expose POP3 and SMTP. See ~/.davmail.properties (though it's easy to configure from the UI as well).

I added DavMail to my "Login Items" so it starts when I login.

Homebrew

See the site for documentation on how to install.

getmail

Install with "brew install getmail". I keep my mail in ~/Mail, see ~/.getmail/getmailrc.

I have a cron job to run getmail every 3 minutes
    */3 * * * * /usr/local/bin/getmail -n -q

sup

sup is based on ruby. I've installed rbenv and ruby 1.9. "gem install sup" should work. (Note that I had trouble linking to ncurses, and had to run "brew link ncurses" before installing sup). See ~/.sup for configuration example.

sendmail

Sending mail is done via the sendmail program that comes with OSX. A bit of configuration is needed though. See /etc/postfix/main.cf and /etc/postfix/sasl_passwd

After the above changes, run the following commands:
    sudo postmap /etc/postfix/sasl_passwd
    sudo postfix reload

That's it, you should be set to go with a decent email client.

I also use iTerm2, which lets me click on a link on sup terminal and open it